Comparative of chemical methods for determination ciprofloxacin hydrochloride- A Review


Ciprofloxacin hydrochloride is a wide-spectrum antibiotic that is active against Gram-positive and Gram-negative bacteria, is now one of the most widely-distributed antibiotics in the United States and Europe. An overview is given dealing with the chemical methods used to determined ciprofloxacin hydrochloride, some of these methods including spectrophotometric, High performance liquid chromatography, Ion-selective electrodes ISEs, based on the concentration range, detection limit,PH, the wavelength, solvent , correlation coefficient, response time, relative standard deviation, recovery, slope, lifetime The main emphasis of this article is directed towards summarizing recent results of this drug during the past several years.
Ciprofloxacin belongs to the second group of quinolone similarities of nalidix acid that has larger influence, lesser harmfulness and a wider antibacterial variety. The highest variance amid the other antibiotics and ciprofloxacin and it can be administrated both orally and parenterally. It is good absorbed and far and wide disseminated into fluids and various body tissues. It is used in a wide-ranging variation of taints of the gastrointestinal tract and urinary tract in addition to soft tissue infections and skin [4]. A number of analytical methods for determined of ciprofloxacin in pharmaceutical dosage forms, bulk, and body fluids are described. Additionally, different analytical methods for the valuation of ciprofloxacin in pharmaceuticals as well as bulk including UV-visible HPLC, and ion selective electrodes ISEs are reported in Table 1, 2, 3. 

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